How Long For Zoloft To Kick In?

How Long For Zoloft To Kick In?

If you’ve just begun taking Zoloft, you’re probably wondering when the medication will start to work. Some symptoms of serotonin-related disorders improve quickly, but SSRIs don’t work fully right away. Serious improvement takes a couple weeks or so longer. Due to the risks associated with SSRI medications—clinical worsening, suicidality, unusual changes in behavior, and so on—anyone taking Zoloft should schedule weekly visits with their doctor to have the treatment evaluated.

Patients should also arrange for family or caregivers to observe them closely and to communicate any behavioral changes with their Zoloft-prescribing physician.

1-2 weeks after taking Zoloft

Most Zoloft patients reach steady-state sertraline plasma after a week or so of taking 50-200 mg per day. Even before mood and behavior improve, other symptoms of depression may subside as well. The following are some good signs that the SSRI is working, and that relief is well on its way.

changes in appetite

decreased need for sleep

improved sleep

increased energy

less disturbances during sleep

3-6 weeks after taking Zoloft

For relief from serotonin-related mental health disorders such as MDD, OCD, PTSD, or PMDD, Zoloft may take some time. Within 3-6 weeks, though, you should experience improvements in at least some of the following areas:






interest in activities



compulsions (repetitive, ritualized behaviors)

feeling worthless/guilty/ hopeless/helpless

obsessions (unwanted/recurrent/disturbing thoughts)

psychomotor agitation or retardation

poor mood

thoughts of suicide

If you don’t experience any of the above by week 6, you may want to request a medication switch. Don’t give up on SSRI’s, though. A lot of people become frustrated and give up on SSRIs after experiencing an unsuccessful treatment, but the truth is that different SSRIs work for different people.

Long-term Zoloft Treatment

If used as prescribed, Zoloft can be a safe, effective antidepressant. Once your mental health condition normalizes, your doctor may recommend long-term Zoloft treatment to prevent the return of symptoms. Only your doctor can determine your proper length of treatment. As your dependence increases, so will your assigned dosage.

Quitting Zoloft Treatment

If you wish to stop Zoloft, be sure to do so under medical supervision. Like any medication that acts on the central nervous system, Zoloft can cause problems if stopped or dramatically decreased suddenly.

Mental health disorders and addiction frequently work together,

especially if you’re taking a prescription medication.

To get help for both, call Blueprints for Recovery today at (888) 744-9969.


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