Learn How Zoloft Works

Learn How Zoloft Works

When a person starts taking Zoloft, it helps to know when to expect the medicine to kick in and start working. Symptoms ease quickly but other some may take a few weeks to ease up before noticeable improvement happens. Regular, frequent visits with a prescribing doctor is important to monitor for treatment including antidepressants due to risks associated with SSRI (selective serotonin reuptake inhibitor) antidepressant medication. Learn more about how Zoloft works.

Common Improvements

1-2 weeks after taking Zoloft

In clinical studies, people taking Zoloft in 50-200 mg doses once a day experienced steady-state sertraline plasma levels approximately one week after starting medication. Some symptoms may improve prior to improved mood or interest in activities. The easing of these symptoms is a good sign the SSRI is working and relief for mood related symptoms is on the way. The most common effects reported include:

  • Changes in appetite
  • Decreased need for sleep
  • Improved sleep
  • Increased energy
  • Less sleep disturbances
  • 3-6 weeks after taking Zoloft

After taking Zoloft regularly, symptoms of mental health disorders such as MDD, OCD, PTSD or PMDD gradually decrease over a period of weeks. Like similar SSRI medications, sertraline may take several weeks to be fully effective. Sufficient time is needed to work prior to asking doctors to switch. Common effects reported include:

  • Improved concentration
  • Improved mood
  • Improved sleep
  • Improved appetite
  • Improved energy
  • Improved interest in activities
  • Lowered irritability

Long Term Treatment

Zoloft can be effective and safe as an antidepressant. Once physical and mental health symptoms normalize, doctors may recommend long-term treatment with Zoloft to help prevent return of symptoms related to mental health disorders. Only a prescribing doctor can determine the length of treatment right for an individual person. Check with a doctor about doses and effects of Zoloft. Doing so under medical supervision is the best way to ensure safe treatment and lower the unnecessary risks to health and well-being.

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